NCCI edits for 81221 Code page: https://localishealth.com/cpt/81221 NCCI release: 2026 C Source: https://www.cms.gov/medicare/coding-billing/national-correct-coding-initiative-ncci-edits NOT SEPARATELY PAYABLE TOGETHER—NO NCCI-ASSOCIATED MODIFIER BYPASSES THE EDIT (modifier indicator 0) 0079U 0079U is Column One, 81221 is Column Two—81221 denies 81220 81220 is Column One, 81221 is Column Two—81221 denies 81222 81221 is Column One, 81222 is Column Two—81222 denies 81223 81223 is Column One, 81221 is Column Two—81221 denies 96523 81221 is Column One, 96523 is Column Two—96523 denies BILLABLE TOGETHER ONLY WHEN AN NCCI-ASSOCIATED MODIFIER IS APPROPRIATE (modifier indicator 1) 0001U 0001U is Column One, 81221 is Column Two—81221 denies 0004M 0004M is Column One, 81221 is Column Two—81221 denies 0005U 0005U is Column One, 81221 is Column Two—81221 denies 0006M 0006M is Column One, 81221 is Column Two—81221 denies 0007M 0007M is Column One, 81221 is Column Two—81221 denies 0008U 0008U is Column One, 81221 is Column Two—81221 denies 0009U 81221 is Column One, 0009U is Column Two—0009U denies 0010U 0010U is Column One, 81221 is Column Two—81221 denies 0011M 0011M is Column One, 81221 is Column Two—81221 denies 0012M 0012M is Column One, 81221 is Column Two—81221 denies 0013M 0013M is Column One, 81221 is Column Two—81221 denies 0016M 0016M is Column One, 81221 is Column Two—81221 denies 0018U 0018U is Column One, 81221 is Column Two—81221 denies 0019U 0019U is Column One, 81221 is Column Two—81221 denies 0022U 0022U is Column One, 81221 is Column Two—81221 denies 0023U 0023U is Column One, 81221 is Column Two—81221 denies 0026U 0026U is Column One, 81221 is Column Two—81221 denies 0036U 0036U is Column One, 81221 is Column Two—81221 denies 0037U 0037U is Column One, 81221 is Column Two—81221 denies 0045U 0045U is Column One, 81221 is Column Two—81221 denies 0047U 0047U is Column One, 81221 is Column Two—81221 denies 0048U 0048U is Column One, 81221 is Column Two—81221 denies 0050U 0050U is Column One, 81221 is Column Two—81221 denies 0055U 0055U is Column One, 81221 is Column Two—81221 denies 0060U 0060U is Column One, 81221 is Column Two—81221 denies 0068U 81221 is Column One, 0068U is Column Two—0068U denies 0069U 0069U is Column One, 81221 is Column Two—81221 denies 0084U 0084U is Column One, 81221 is Column Two—81221 denies 0086U 81221 is Column One, 0086U is Column Two—0086U denies 0087U 0087U is Column One, 81221 is Column Two—81221 denies 0088U 0088U is Column One, 81221 is Column Two—81221 denies 0089U 0089U is Column One, 81221 is Column Two—81221 denies 0090U 0090U is Column One, 81221 is Column Two—81221 denies 0101U 0101U is Column One, 81221 is Column Two—81221 denies 0102U 0102U is Column One, 81221 is Column Two—81221 denies 0103U 0103U is Column One, 81221 is Column Two—81221 denies 0108U 0108U is Column One, 81221 is Column Two—81221 denies 0112U 81221 is Column One, 0112U is Column Two—0112U denies 0113U 0113U is Column One, 81221 is Column Two—81221 denies 0115U 81221 is Column One, 0115U is Column Two—0115U denies 0118U 0118U is Column One, 81221 is Column Two—81221 denies 0120U 0120U is Column One, 81221 is Column Two—81221 denies 0129U 0129U is Column One, 81221 is Column Two—81221 denies 0130U 0130U is Column One, 81221 is Column Two—81221 denies 0133U 0133U is Column One, 81221 is Column Two—81221 denies 0134U 0134U is Column One, 81221 is Column Two—81221 denies 0140U 81221 is Column One, 0140U is Column Two—0140U denies 0141U 81221 is Column One, 0141U is Column Two—0141U denies 0142U 81221 is Column One, 0142U is Column Two—0142U denies 0156U 0156U is Column One, 81221 is Column Two—81221 denies 0162U 0162U is Column One, 81221 is Column Two—81221 denies 0170U 0170U is Column One, 81221 is Column Two—81221 denies 0171U 0171U is Column One, 81221 is Column Two—81221 denies 0174U 0174U is Column One, 81221 is Column Two—81221 denies 0202U 81221 is Column One, 0202U is Column Two—0202U denies 0211U 0211U is Column One, 81221 is Column Two—81221 denies 0212U 0212U is Column One, 81221 is Column Two—81221 denies 0213U 0213U is Column One, 81221 is Column Two—81221 denies 0228U 0228U is Column One, 81221 is Column Two—81221 denies 0232U 0232U is Column One, 81221 is Column Two—81221 denies 0237U 0237U is Column One, 81221 is Column Two—81221 denies 0238U 0238U is Column One, 81221 is Column Two—81221 denies 0239U 0239U is Column One, 81221 is Column Two—81221 denies 0242U 0242U is Column One, 81221 is Column Two—81221 denies 0244U 0244U is Column One, 81221 is Column Two—81221 denies 0245U 0245U is Column One, 81221 is Column Two—81221 denies 0246U 0246U is Column One, 81221 is Column Two—81221 denies 0249U 0249U is Column One, 81221 is Column Two—81221 denies 0250U 0250U is Column One, 81221 is Column Two—81221 denies 0253U 0253U is Column One, 81221 is Column Two—81221 denies 0254U 0254U is Column One, 81221 is Column Two—81221 denies 0285U 0285U is Column One, 81221 is Column Two—81221 denies 0287U 0287U is Column One, 81221 is Column Two—81221 denies 0288U 0288U is Column One, 81221 is Column Two—81221 denies 0289U 0289U is Column One, 81221 is Column Two—81221 denies 0290U 0290U is Column One, 81221 is Column Two—81221 denies 0296U 0296U is Column One, 81221 is Column Two—81221 denies 0297U 0297U is Column One, 81221 is Column Two—81221 denies 0298U 0298U is Column One, 81221 is Column Two—81221 denies 0300U 0300U is Column One, 81221 is Column Two—81221 denies 0306U 0306U is Column One, 81221 is Column Two—81221 denies 0307U 0307U is Column One, 81221 is Column Two—81221 denies 0313U 0313U is Column One, 81221 is Column Two—81221 denies 0314U 0314U is Column One, 81221 is Column Two—81221 denies 0315U 0315U is Column One, 81221 is Column Two—81221 denies 0318U 0318U is Column One, 81221 is Column Two—81221 denies 0319U 0319U is Column One, 81221 is Column Two—81221 denies 0320U 0320U is Column One, 81221 is Column Two—81221 denies 0321U 81221 is Column One, 0321U is Column Two—0321U denies 0326U 0326U is Column One, 81221 is Column Two—81221 denies 0327U 0327U is Column One, 81221 is Column Two—81221 denies 0329U 0329U is Column One, 81221 is Column Two—81221 denies 0330U 81221 is Column One, 0330U is Column Two—0330U denies 0331U 0331U is Column One, 81221 is Column Two—81221 denies 0334U 0334U is Column One, 81221 is Column Two—81221 denies 0336U 0336U is Column One, 81221 is Column Two—81221 denies 0339U 0339U is Column One, 81221 is Column Two—81221 denies 0340U 0340U is Column One, 81221 is Column Two—81221 denies 0343U 0343U is Column One, 81221 is Column Two—81221 denies 0363U 0363U is Column One, 81221 is Column Two—81221 denies 0392U 0392U is Column One, 81221 is Column Two—81221 denies 0398U 0398U is Column One, 81221 is Column Two—81221 denies 0400U 0400U is Column One, 81221 is Column Two—81221 denies 0403U 0403U is Column One, 81221 is Column Two—81221 denies 0405U 0405U is Column One, 81221 is Column Two—81221 denies 0409U 0409U is Column One, 81221 is Column Two—81221 denies 0410U 0410U is Column One, 81221 is Column Two—81221 denies 0411U 0411U is Column One, 81221 is Column Two—81221 denies 0412U 0412U is Column One, 81221 is Column Two—81221 denies 0414U 0414U is Column One, 81221 is Column Two—81221 denies 0417U 0417U is Column One, 81221 is Column Two—81221 denies 0418U 0418U is Column One, 81221 is Column Two—81221 denies 0419U 0419U is Column One, 81221 is Column Two—81221 denies 0420U 0420U is Column One, 81221 is Column Two—81221 denies 0424U 0424U is Column One, 81221 is Column Two—81221 denies 0425U 0425U is Column One, 81221 is Column Two—81221 denies 0426U 0426U is Column One, 81221 is Column Two—81221 denies 0429U 81221 is Column One, 0429U is Column Two—0429U denies 0431U 0431U is Column One, 81221 is Column Two—81221 denies 0434U 0434U is Column One, 81221 is Column Two—81221 denies 0437U 0437U is Column One, 81221 is Column Two—81221 denies 0438U 0438U is Column One, 81221 is Column Two—81221 denies 0449U 0449U is Column One, 81221 is Column Two—81221 denies 0454U 0454U is Column One, 81221 is Column Two—81221 denies 0469U 0469U is Column One, 81221 is Column Two—81221 denies 0489U 0489U is Column One, 81221 is Column Two—81221 denies 80503 81221 is Column One, 80503 is Column Two—80503 denies 80504 81221 is Column One, 80504 is Column Two—80504 denies 80505 81221 is Column One, 80505 is Column Two—80505 denies 80506 81221 is Column One, 80506 is Column Two—80506 denies 81228 81228 is Column One, 81221 is Column Two—81221 denies 81229 81229 is Column One, 81221 is Column Two—81221 denies 81410 81410 is Column One, 81221 is Column Two—81221 denies 81411 81411 is Column One, 81221 is Column Two—81221 denies 81412 81412 is Column One, 81221 is Column Two—81221 denies 81413 81413 is Column One, 81221 is Column Two—81221 denies 81414 81414 is Column One, 81221 is Column Two—81221 denies 81415 81415 is Column One, 81221 is Column Two—81221 denies 81416 81416 is Column One, 81221 is Column Two—81221 denies 81417 81417 is Column One, 81221 is Column Two—81221 denies 81418 81418 is Column One, 81221 is Column Two—81221 denies 81420 81420 is Column One, 81221 is Column Two—81221 denies 81422 81422 is Column One, 81221 is Column Two—81221 denies 81425 81425 is Column One, 81221 is Column Two—81221 denies 81426 81426 is Column One, 81221 is Column Two—81221 denies 81427 81427 is Column One, 81221 is Column Two—81221 denies 81430 81430 is Column One, 81221 is Column Two—81221 denies 81431 81431 is Column One, 81221 is Column Two—81221 denies 81432 81432 is Column One, 81221 is Column Two—81221 denies 81434 81434 is Column One, 81221 is Column Two—81221 denies 81435 81435 is Column One, 81221 is Column Two—81221 denies 81437 81437 is Column One, 81221 is Column Two—81221 denies 81439 81439 is Column One, 81221 is Column Two—81221 denies 81440 81440 is Column One, 81221 is Column Two—81221 denies 81441 81441 is Column One, 81221 is Column Two—81221 denies 81442 81442 is Column One, 81221 is Column Two—81221 denies 81443 81443 is Column One, 81221 is Column Two—81221 denies 81445 81445 is Column One, 81221 is Column Two—81221 denies 81448 81448 is Column One, 81221 is Column Two—81221 denies 81449 81449 is Column One, 81221 is Column Two—81221 denies 81450 81450 is Column One, 81221 is Column Two—81221 denies 81451 81451 is Column One, 81221 is Column Two—81221 denies 81455 81455 is Column One, 81221 is Column Two—81221 denies 81456 81456 is Column One, 81221 is Column Two—81221 denies 81460 81460 is Column One, 81221 is Column Two—81221 denies 81465 81465 is Column One, 81221 is Column Two—81221 denies 81470 81470 is Column One, 81221 is Column Two—81221 denies 81471 81471 is Column One, 81221 is Column Two—81221 denies 81493 81493 is Column One, 81221 is Column Two—81221 denies 81504 81504 is Column One, 81221 is Column Two—81221 denies 81507 81507 is Column One, 81221 is Column Two—81221 denies 81513 81221 is Column One, 81513 is Column Two—81513 denies 81518 81518 is Column One, 81221 is Column Two—81221 denies 81519 81519 is Column One, 81221 is Column Two—81221 denies 81520 81520 is Column One, 81221 is Column Two—81221 denies 81521 81521 is Column One, 81221 is Column Two—81221 denies 81523 81523 is Column One, 81221 is Column Two—81221 denies 81525 81525 is Column One, 81221 is Column Two—81221 denies 81528 81528 is Column One, 81221 is Column Two—81221 denies 81529 81529 is Column One, 81221 is Column Two—81221 denies 81540 81540 is Column One, 81221 is Column Two—81221 denies 81541 81541 is Column One, 81221 is Column Two—81221 denies 81546 81546 is Column One, 81221 is Column Two—81221 denies 81551 81551 is Column One, 81221 is Column Two—81221 denies 81552 81552 is Column One, 81221 is Column Two—81221 denies 81554 81554 is Column One, 81221 is Column Two—81221 denies 81595 81595 is Column One, 81221 is Column Two—81221 denies 84311 81221 is Column One, 84311 is Column Two—84311 denies 87140 81221 is Column One, 87140 is Column Two—87140 denies 87143 81221 is Column One, 87143 is Column Two—87143 denies 87147 81221 is Column One, 87147 is Column Two—87147 denies 87149 81221 is Column One, 87149 is Column Two—87149 denies 87150 81221 is Column One, 87150 is Column Two—87150 denies 87152 81221 is Column One, 87152 is Column Two—87152 denies 87153 81221 is Column One, 87153 is Column Two—87153 denies 87154 81221 is Column One, 87154 is Column Two—87154 denies 87158 81221 is Column One, 87158 is Column Two—87158 denies 87468 81221 is Column One, 87468 is Column Two—87468 denies 87469 81221 is Column One, 87469 is Column Two—87469 denies 87471 81221 is Column One, 87471 is Column Two—87471 denies 87472 81221 is Column One, 87472 is Column Two—87472 denies 87475 81221 is Column One, 87475 is Column Two—87475 denies 87476 81221 is Column One, 87476 is Column Two—87476 denies 87478 81221 is Column One, 87478 is Column Two—87478 denies 87480 81221 is Column One, 87480 is Column Two—87480 denies 87481 81221 is Column One, 87481 is Column Two—87481 denies 87482 81221 is Column One, 87482 is Column Two—87482 denies 87483 81221 is Column One, 87483 is Column Two—87483 denies 87484 81221 is Column One, 87484 is Column Two—87484 denies 87485 81221 is Column One, 87485 is Column Two—87485 denies 87486 81221 is Column One, 87486 is Column Two—87486 denies 87487 81221 is Column One, 87487 is Column Two—87487 denies 87490 81221 is Column One, 87490 is Column Two—87490 denies 87491 81221 is Column One, 87491 is Column Two—87491 denies 87492 81221 is Column One, 87492 is Column Two—87492 denies 87493 81221 is Column One, 87493 is Column Two—87493 denies 87495 81221 is Column One, 87495 is Column Two—87495 denies 87496 81221 is Column One, 87496 is Column Two—87496 denies 87497 81221 is Column One, 87497 is Column Two—87497 denies 87498 81221 is Column One, 87498 is Column Two—87498 denies 87500 81221 is Column One, 87500 is Column Two—87500 denies 87501 81221 is Column One, 87501 is Column Two—87501 denies 87502 81221 is Column One, 87502 is Column Two—87502 denies 87503 81221 is Column One, 87503 is Column Two—87503 denies 87505 81221 is Column One, 87505 is Column Two—87505 denies 87506 81221 is Column One, 87506 is Column Two—87506 denies 87507 81221 is Column One, 87507 is Column Two—87507 denies 87510 81221 is Column One, 87510 is Column Two—87510 denies 87511 81221 is Column One, 87511 is Column Two—87511 denies 87512 81221 is Column One, 87512 is Column Two—87512 denies 87516 81221 is Column One, 87516 is Column Two—87516 denies 87517 81221 is Column One, 87517 is Column Two—87517 denies 87520 81221 is Column One, 87520 is Column Two—87520 denies 87521 81221 is Column One, 87521 is Column Two—87521 denies 87522 81221 is Column One, 87522 is Column Two—87522 denies 87525 81221 is Column One, 87525 is Column Two—87525 denies 87526 81221 is Column One, 87526 is Column Two—87526 denies 87527 81221 is Column One, 87527 is Column Two—87527 denies 87528 81221 is Column One, 87528 is Column Two—87528 denies 87529 81221 is Column One, 87529 is Column Two—87529 denies 87530 81221 is Column One, 87530 is Column Two—87530 denies 87531 81221 is Column One, 87531 is Column Two—87531 denies 87532 81221 is Column One, 87532 is Column Two—87532 denies 87533 81221 is Column One, 87533 is Column Two—87533 denies 87534 81221 is Column One, 87534 is Column Two—87534 denies 87535 81221 is Column One, 87535 is Column Two—87535 denies 87536 81221 is Column One, 87536 is Column Two—87536 denies 87537 81221 is Column One, 87537 is Column Two—87537 denies 87538 81221 is Column One, 87538 is Column Two—87538 denies 87539 81221 is Column One, 87539 is Column Two—87539 denies 87540 81221 is Column One, 87540 is Column Two—87540 denies 87541 81221 is Column One, 87541 is Column Two—87541 denies 87542 81221 is Column One, 87542 is Column Two—87542 denies 87550 81221 is Column One, 87550 is Column Two—87550 denies 87551 81221 is Column One, 87551 is Column Two—87551 denies 87552 81221 is Column One, 87552 is Column Two—87552 denies 87555 81221 is Column One, 87555 is Column Two—87555 denies 87556 81221 is Column One, 87556 is Column Two—87556 denies 87557 81221 is Column One, 87557 is Column Two—87557 denies 87560 81221 is Column One, 87560 is Column Two—87560 denies 87561 81221 is Column One, 87561 is Column Two—87561 denies 87562 81221 is Column One, 87562 is Column Two—87562 denies 87580 81221 is Column One, 87580 is Column Two—87580 denies 87581 81221 is Column One, 87581 is Column Two—87581 denies 87582 81221 is Column One, 87582 is Column Two—87582 denies 87590 81221 is Column One, 87590 is Column Two—87590 denies 87591 81221 is Column One, 87591 is Column Two—87591 denies 87592 81221 is Column One, 87592 is Column Two—87592 denies 87623 81221 is Column One, 87623 is Column Two—87623 denies 87624 81221 is Column One, 87624 is Column Two—87624 denies 87625 81221 is Column One, 87625 is Column Two—87625 denies 87631 81221 is Column One, 87631 is Column Two—87631 denies 87632 81221 is Column One, 87632 is Column Two—87632 denies 87633 81221 is Column One, 87633 is Column Two—87633 denies 87636 81221 is Column One, 87636 is Column Two—87636 denies 87637 81221 is Column One, 87637 is Column Two—87637 denies 87640 81221 is Column One, 87640 is Column Two—87640 denies 87641 81221 is Column One, 87641 is Column Two—87641 denies 87650 81221 is Column One, 87650 is Column Two—87650 denies 87651 81221 is Column One, 87651 is Column Two—87651 denies 87652 81221 is Column One, 87652 is Column Two—87652 denies 87653 81221 is Column One, 87653 is Column Two—87653 denies 87660 81221 is Column One, 87660 is Column Two—87660 denies 87661 81221 is Column One, 87661 is Column Two—87661 denies 87797 81221 is Column One, 87797 is Column Two—87797 denies 87798 81221 is Column One, 87798 is Column Two—87798 denies 87799 81221 is Column One, 87799 is Column Two—87799 denies 87800 81221 is Column One, 87800 is Column Two—87800 denies 87801 81221 is Column One, 87801 is Column Two—87801 denies 88271 81221 is Column One, 88271 is Column Two—88271 denies 88272 81221 is Column One, 88272 is Column Two—88272 denies 88273 81221 is Column One, 88273 is Column Two—88273 denies 88274 81221 is Column One, 88274 is Column Two—88274 denies 88275 81221 is Column One, 88275 is Column Two—88275 denies 88291 81221 is Column One, 88291 is Column Two—88291 denies 88364 81221 is Column One, 88364 is Column Two—88364 denies 88365 81221 is Column One, 88365 is Column Two—88365 denies 88366 81221 is Column One, 88366 is Column Two—88366 denies 88367 81221 is Column One, 88367 is Column Two—88367 denies 88368 81221 is Column One, 88368 is Column Two—88368 denies 88369 81221 is Column One, 88369 is Column Two—88369 denies 88373 81221 is Column One, 88373 is Column Two—88373 denies 88374 81221 is Column One, 88374 is Column Two—88374 denies 88377 81221 is Column One, 88377 is Column Two—88377 denies G0452 81221 is Column One, G0452 is Column Two—G0452 denies G0476 81221 is Column One, G0476 is Column Two—G0476 denies MUE units per patient per date of service: not published